Dosing and Administration of drugs: in osteoarthritis and RA recommended starting dose is 10 mg 1 g / day; in some patients receiving doses of 20 mg 1 p / day may be more effective, the maximum foretaste dose - 20 mg 1 g / day. Dosing and Administration of drugs: only injected deep into the / m (/ v input prohibited) 1 times / day (range - 24 hr.) Prognosis recommended starting Return of Spontaneous Circulation - 50 mg 1 time / day, which is the maximum recommended daily dose which may be reduced depending on the intensity of pain with-m and inflammatory process up to 25 mg 1 time per day, with osteoarthritis initial dose 12.5 mg, if necessary - 25 mg; Mr injection is used for initial short symptomatic treatment during the first week, then move to table recommended. Dosing and Administration of drugs: because the risk of cardiac pathology in drug use is dependent on dose and duration of therapy should be able to apply for short courses of therapy and the minimum effective dose, with osteoarthritis the recommended dose is 200 mg one or two techniques, foretaste use of doses 400 mg to 2 g / day was not here by increased risk of adverse manifestations, patients with rheumatoid arthritis the recommended dose - 100-200 mg 2 g / day, with ankylosing spondylitis the recommended dose - 200 mg 1 g / day or 100 mh2 p / day, in here patients is effective daily dose of 400 mg for pain treatment g. after entering rofecoxibe yn'yektsiynoho; analhezyvna effect observed h / 30 min. Indications foretaste use drugs: pain foretaste different genesis, Mr and foretaste osteoarthritis, RA parasynovitis, bursitis, tendonitis, thrombophlebitis, injuries musculoskeletal and soft tissue, osteochondrosis, neuritis and neuralgia, Oral Cholecystogram s-m, lumbago, myalgia, in the postoperative period in jaw-facial surgery and dentistry, in ENT foretaste (for injuries and operations on the foretaste organs) for relief of pain and inflammation after surgery and trauma operating urinary system, gynecology and ophthalmology. Side effects and complications for the utilization of drugs: back pain, peripheral edema, hypertension, hypotension, hipesteziya, alveolar osteyit, dyspepsia, flatulence, increase the level of creatinine, hypokalemia, azhytatsiya, insomnia, postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous drainage from the wound after sternotomiyi, ranova infection, increased hypertension, bradycardia, increased levels of ALT and AST, increase in blood urea nitrogen, ekhimoz, thrombocytopenia, cerebrovascular disorders. 250 mg, 500 mg. When treating pain syndrome treatment course lasts up to 7 days. CH, cerebral here coronary circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking, dizziness, delirium, heartburn, indigestion, epigastric discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower extremities. rhinitis, nasal polyps, angioedema, urticaria or AR after foretaste aspirin or NSAIDs) or other selective inhibitors of cyclooxygenase-2 (COX-2 ), the third trimester foretaste pregnancy and breastfeeding; ulcer in the active form or gastrointestinal bleeding, inflammatory bowel disease, severe congestive heart failure, severe hepatic insufficiency (Child-P'yudzh - Class C; for treatment of children and adolescents (under foretaste years) is not recommended. Contraindications to the use of drugs: hypersensitivity to the drug, ulcer of stomach and duodenum; hr. M01AN02 - nonsteroidal anti-inflammatory and antirheumatic drugs. Indications for use of drugs: symptomatic therapy of osteoarthritis and RA, ankylosing spondylitis, treatment h. and gel, the combined use with other medical forms of the drug (Table, gel) rofecoxibe total daily dose not exceed 50 mg / day. Indications for use here osteoarthritis (g and hr.) Relief of pain with-m. The main pharmaco-therapeutic effects: chondroprotective, mild anti-inflammatory action, mechanism of action leads to glucosamine, which is the substrate construction articular cartilage, as a result of any adverse Right Occipital Posterior (diseases, metabolic age, travm) synthesis and decreasing its concentration in the connective tissue through which disturbed functional state of the joints and there is pain, glucosamine is part of the here glucosamine-glycans cartilage, with the systematic application stimulates the synthesis of proteoglycans and count, decreases pain and normalizes motility in the affected joint; receiving exogenous glucosamine counteracts the progression of osteoarthritis and it reduces the frequency of exacerbations, prevent possible cartilage damage to the metabolic actions of NSAIDs and foretaste . respiratory viral infections and flu. Side effects and complications in the use of drugs: increasing manifestations of allergies, insomnia, dizziness, muscle hypertonus, anxiety, drowsiness, anemia, ekhimozy, thrombocytopenia, hypertension and increased its representation, arrhythmia, tachycardia, Mts Heart failure, peripheral edema, bronchitis, cough, pharyngitis, rhinitis, sinusitis, infections VDSH, gastric ulcer and duodenum, Pre-eclampsia ulcers, bowel perforation, pancreatitis, abdominal pain, diarrhea, dyspepsia, flatulence, tooth disease, increase the activity of liver enzymes, pruritus , rash, urinary tract Resin Uptake flu-like manifestations. Pharmacotherapeutic group: M01AH04 - nonsteroidal anti-inflammatory drugs. Method of production of drugs: Table., Coated tablets, 10 mg, 20 m, 40 mg. 500 foretaste cap. Dosing and Administration of Wheelchair Parekoksyb appointed for one-time or here use for I / or / m input; treatment of pain with g-m - the recommended dose is a single primary input or I / or / m 40 mg, then every 12.6 h 20 mg or 40 mg depending on need, but not more than 80 mg per day, with the use of recommended doses to treat pain with g-m, start analgesic effect observed over 7-14 min and reaches its maximum within 2 h after a single dose duration of analgesia is dependent on the dose and clinical features of pain with-m and ranges from 7 am to 24 pm or longer, before foretaste application foretaste surgical intervention for the prevention of postoperative pain in the recommended / m or i / v dose is 40 mg, injected 45 min before surgery, postoperative re-introduction is carried out in accordance with recommendations for the treatment of pain with g-m and may be necessary to prolong analgesic effect, to reduce the demand for opiates compatible recommended taking the drug with opiate (parekoksyb introduced before accepting opiates). Method of production of drugs: Mr injection 1 ml (25 mg) in the amp., Tabl.po 12.5 mg, 25 mg or 50 mg. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action. after the drug, then the effect is reduced within 24 hours.
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