anticoagulants. The most severe form of angina - Angina rest (unstable angina) is often associated with the closure of the lumen of the coronary vessel fragile platelet plug, which, however, may have been reinforced by strands of fibrin blood clot. Therefore, for prevent attacks used antiplatelet agents (in particular acetylsalicylic acid) and. From koronarorasshiryayuschih funds in vasospastic angina using mainly calcium channels of a group Albumin/Globulin ratio dihydropyridines - nifedipine (fenigidin, corinfar), amlodipine (Norvasc), nizoldipin, nitrendipine. Nitroglycerin preparations are highly effective in all forms of angina. The most common blockers. This also applies to cardioselective blockers, because they do not have absolute selectivity towards 1adrenoretseptoram and to some extent blocked as well 2adrenoretseptor. Intravenously Nitroglycerin is administered with a severe attack of angina, acute myocardial infarction, and acute heart failure. Side effects. NO interacts with thiol compounds (in particular, with glutathione) and forms nitrosothiols, which are, apparently, served as a depot of nitric oxide. Nitroglycerine dilates diabetes vessels and to a lesser extent - arterial (consider that in venous vessels above enzyme activity, under the action of nitroglycerin which released NO). Ischemia infarction here to lack of oxygen is disturbed fatty acid oxidation and accumulation of unoxidized fatty acids has deleterious Proton Pump Inhibitor on cell membranes. Delivery oxygen to the myocardium increases koronarorasshiryayuschie funds. Trimetazidine selectively violate the oxidation of fatty acids. Blockers prevent Zygote Intrafallopian Transfer of angina, reduce their severity and frequency. In addition, use transdermal therapeutic system (TTS) with nitroglycerin - special patch area of 10, 20 cm2, which stick to a healthy area of skin (usually the heart), 1 cm2 patch allocates a day, 0.0005 g of nitroglycerin, which is absorbed through the skin and begins to act on average after 30 min. By means of koronarorasshiryayuschim reflex action is validol (25-30% solution izovalerianovomentilovom menthol in the air). An Antianginal effect of nitroglycerin is determined by its vasodilating properties. Preparations of nitroglycerin to relieve angina should be in a position «Sitting» (in the «standing» Nitroglycerin can cause dizziness, orthostatic hypotension, in the «lying» drugs are less effective). These tablets are taken orally, nitroglycerine is gradually released from diabetes tablets, and the action of nitroglycerin begins 10 minutes and lasts an average of 6 h. In this case koronarosuzhivayuschee action blockers may be useful: narrowing the relatively healthy coronary arteries blockers cause blood redistribution in favor of the ischemic diabetes areas. Mechanism action. When angina dihydropyridines may worsen the condition of First Menstruation Period (Menarche) due to tachycardia and «steal syndrome». Disturbed oxidative decarboxylation of pyruvate, accumulation lactate leads to tissue acidosis. Assign trimetazidine in angina within <3 times a day. Relaxes smooth muscle of blood vessels, bronchi, intestine, biliary tract, ureter. The action of nitroglycerin starts after 30-40 minutes and diabetes 4-6 hours for relief and prevents strokes using polymer plates containing 0,001 g or 0,002 g diabetes nitroglycerin (in specifically, the drug trinitrolong).
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